Mixed models for longitudinal left-censored repeated measures

Mixed models for longitudinal left-censored repeated measures

Longitudinal studies could be complicated by left-censored repeated measures. For example, in Human Immunodeficiency Virus infection, there is a detection limit of the assay used to quantify the plasma viral load. Simple imputation of the limit of the detection or of half of this limit for left-censored measures biases estimations and their standard errors. In this paper, we review two likeliho...

Censored mixed-effects models for irregularly observed repeated measures with applications to HIV viral loads

In some AIDS clinical trials, the HIV-1 RNA measurements are collected irregularly over time and are often subject to some upper and lower detection limits, depending on the quantification assays. Linear and nonlinear mixed-effects models, with modifications to accommodate censored observations, are routinely used to analyze this type of data Vaida & Liu (2009); Matos et al. (2013a). This paper...

Transition Models for Analyzing Longitudinal Data with Bivariate Mixed Ordinal and Nominal Responses

In many longitudinal studies, nominal and ordinal mixed bivariate responses are measured. In these studies, the aim is to investigate the effects of explanatory variables on these time-related responses. A regression analysis for these types of data must allow for the correlation among responses during the time. To analyze such ordinal-nominal responses, using a proposed weighting approach, an ...

Random coefficient repeated measures models

Inference for Censored Quantile Regression Models in Longitudinal Studies

We develop inference procedures for longitudinal data where some of the measurements are censored by fixed constants. We consider a semi-parametric quantile regression model that makes no distributional assumptions. Our research is motivated by the lack of proper inference procedures for data from biomedical studies where measurements are censored due to a fixed quantification limit. In such st...